We are using on the Page_Load event.
A simple work around is to redirect to another page. It could simply be a 'Signature accepted" page and then it could automatically close itself which leaves the first page which did all the heavy lifting released an ready for reuse. However, the Response.Redirect has its own issues and results in a page display error (problem is reported and posted elsewhere).
We do have a workaround, but it's only good during development, so will need the proper fix.
Mike